Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

AIMS: 3′,5′-Cyclic adenosine monophosphate (cAMP) signals in the heart are often confined to concentration microdomains shaped by cAMP diffusion and enzymatic degradation. While the importance of phosphodiesterases (degradative enzymes) in sculpting cAMP microdomains is well established in cardiomyo...

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Publicado en:Cardiovasc Res
Autores principales: Richards, Mark, Lomas, Oliver, Jalink, Kees, Ford, Kerrie L., Vaughan-Jones, Richard D., Lefkimmiatis, Konstantinos, Swietach, Pawel
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872880/
https://ncbi.nlm.nih.gov/pubmed/27089919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw080
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