Facilitation by intracellular carbonic anhydrase of Na(+)–HCO(3)(−) co-transport but not Na(+)/H(+) exchange activity in the mammalian ventricular myocyte

Carbonic anhydrase enzymes (CAs) catalyse the reversible hydration of CO(2) to H(+) and HCO(3)(−) ions. This catalysis is proposed to be harnessed by acid/base transporters, to facilitate their transmembrane flux activity, either through direct protein–protein binding (a ‘transport metabolon’) or lo...

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Autori principali: Villafuerte, Francisco C, Swietach, Pawel, Youm, Jae-Boum, Ford, Kerrie, Cardenas, Rosa, Supuran, Claudiu T, Cobden, Philip M, Rohling, Mala, Vaughan-Jones, Richard D
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons Ltd 2014
Soggetti:
Cardiovascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948559/
https://ncbi.nlm.nih.gov/pubmed/24297849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.265439
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