Sarcolemmal localisation of Na(+)/H(+) exchange and Na(+)–HCO(3)(−) co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes

Membrane acid extrusion by Na(+)/H(+) exchange (NHE1) and Na(+)–HCO(3)(−) co-transport (NBC) is essential for maintaining a low cytoplasmic [H(+)] (∼60 nm, equivalent to an intracellular pH (pH(i)) of 7.2). This protects myocardial function from the high chemical reactivity of H(+) ions, universal e...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Garciarena, Carolina D, Ma, Yu-ling, Swietach, Pawel, Huc, Laurence, Vaughan-Jones, Richard D
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2013
Ämnen:
Cardiovascular
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650695/
https://ncbi.nlm.nih.gov/pubmed/23420656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.249664
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