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Sarcolemmal localisation of Na(+)/H(+) exchange and Na(+)–HCO(3)(−) co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes
Membrane acid extrusion by Na(+)/H(+) exchange (NHE1) and Na(+)–HCO(3)(−) co-transport (NBC) is essential for maintaining a low cytoplasmic [H(+)] (∼60 nm, equivalent to an intracellular pH (pH(i)) of 7.2). This protects myocardial function from the high chemical reactivity of H(+) ions, universal e...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650695/ https://ncbi.nlm.nih.gov/pubmed/23420656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.249664 |
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