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Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes

It is often assumed that pH(i) is spatially uniform within cells. A double-barreled microperfusion system was used to apply solutions of weak acid (acetic acid, CO(2)) or base (ammonia) to localized regions of an isolated ventricular myocyte (guinea pig). A stable, longitudinal pH(i) gradient (up to...

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Hlavní autoři: Swietach, Pawel, Leem, Chae-Hun, Spitzer, Kenneth W., Vaughan-Jones, Richard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305395/
https://ncbi.nlm.nih.gov/pubmed/15653720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.051391
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