Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

AIMS: 3′,5′-Cyclic adenosine monophosphate (cAMP) signals in the heart are often confined to concentration microdomains shaped by cAMP diffusion and enzymatic degradation. While the importance of phosphodiesterases (degradative enzymes) in sculpting cAMP microdomains is well established in cardiomyo...

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Bibliografiske detaljer
Udgivet i:Cardiovasc Res
Main Authors: Richards, Mark, Lomas, Oliver, Jalink, Kees, Ford, Kerrie L., Vaughan-Jones, Richard D., Lefkimmiatis, Konstantinos, Swietach, Pawel
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872880/
https://ncbi.nlm.nih.gov/pubmed/27089919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw080
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