Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite derived phospholipase

Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and cutaneous inflammation play a role in pathogenesis. Mechanisms underlying the associated inflammation are not fully understood, and while CD1a-expressing Langerhans cells are known to be enriched within lesions, the...

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Publicado no:Sci Transl Med
Main Authors: Jarrett, Rachael, Salio, Mariolina, Lloyd-Lavery, Antonia, Subramaniam, Sumithra, Bourgeois, Elvire, Archer, Charles, Cheung, Ka Lun, Hardman, Clare, Chandler, David, Salimi, Maryam, Gutowska-Owsiak, Danuta, de la Serna, Jorge Bernardino, Fallon, Padraic G., Jolin, Helen, Mckenzie, Andrew, Dziembowski, Andrzej, Podobas, Ewa Izabela, Bal, Wojciech, Johnson, David, Moody, D Branch, Cerundolo, Vincenzo, Ogg, Graham
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872823/
https://ncbi.nlm.nih.gov/pubmed/26865566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad6833
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