Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response. Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen-presenting Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high...

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Vydáno v:J Exp Med
Hlavní autoři: Cheung, Ka Lun, Jarrett, Rachael, Subramaniam, Sumithra, Salimi, Maryam, Gutowska-Owsiak, Danuta, Chen, Yi-Ling, Hardman, Clare, Xue, Luzheng, Cerundolo, Vincenzo, Ogg, Graham
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068234/
https://ncbi.nlm.nih.gov/pubmed/27670592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160258
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