HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells

Activator protein 1 (AP-1) is a transcriptional factor composed of the dimeric members of bZIP proteins, which are frequently deregulated in human cancer cells. In this study, we aimed to identify an oncogenic AP-1 dimer critical for the proliferation of neuroblastoma cells and to investigate whethe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: He, Weiwen, Wu, Yanna, Tang, Xiaomei, Xia, Yong, He, Guozhen, Min, Zhiqun, Li, Chun, Xiong, Shiqiu, Shi, Zhi, Lu, Yongjian, Yuan, Zhongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872745/
https://ncbi.nlm.nih.gov/pubmed/26734995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6797
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