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G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA

The present study characterized the signalling pathways initiated by the bioactive lipid, LPA (lysophosphatidic acid) in smooth muscle. Expression of LPA(3) receptors, but not LPA(1) and LPA(2), receptors was demonstrated by Western blot analysis. LPA stimulated phosphoinositide hydrolysis, PKC (pro...

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Publicat a:Biochem J
Autors principals: Sriwai, Wimolpak, Zhou, Huiping, Murthy, Karnam S.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872639/
https://ncbi.nlm.nih.gov/pubmed/18237278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/bj20071299
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