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The mutation spectrum in genomic late replication domains shapes mammalian GC content

Genome sequence compositions and epigenetic organizations are correlated extensively across multiple length scales. Replication dynamics, in particular, is highly correlated with GC content. We combine genome-wide time of replication (ToR) data, topological domains maps and detailed functional epige...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Kenigsberg, Ephraim, Yehuda, Yishai, Marjavaara, Lisette, Keszthelyi, Andrea, Chabes, Andrei, Tanay, Amos, Simon, Itamar
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872117/
https://ncbi.nlm.nih.gov/pubmed/27085808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw268
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