Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer

Rbfox proteins regulate tissue-specific splicing by targeting a conserved GCAUG sequence within pre-mRNAs. We report here that sequence-specific binding of the conserved Rbfox RRM to miRNA precursors containing the same sequence motif in their terminal loops, including miR-20b and miR-107, suppresse...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Chen, Yu, Zubovic, Lorena, Yang, Fan, Godin, Katherine, Pavelitz, Tom, Castellanos, Javier, Macchi, Paolo, Varani, Gabriele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872098/
https://ncbi.nlm.nih.gov/pubmed/27001519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw177
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