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Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE

A crucial component of the human mitochondrial DNA replisome is the ring-shaped helicase TWINKLE—a phage T7-gene 4-like protein expressed in the nucleus and localized in the human mitochondria. Our previous studies showed that despite being a helicase, TWINKLE has unique DNA annealing activity. At t...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Sen, Doyel, Patel, Gayatri, Patel, Smita S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872091/
https://ncbi.nlm.nih.gov/pubmed/26887820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw098
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