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The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
Mitochondrial DNA replication is performed by a simple machinery, containing the TWINKLE DNA helicase, a single-stranded DNA-binding protein, and the mitochondrial DNA polymerase γ. In addition, mitochondrial RNA polymerase is required for primer formation at the origins of DNA replication. TWINKLE...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241658/ https://ncbi.nlm.nih.gov/pubmed/21840902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr653 |
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