Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

The majority of mitochondrial DNA replication events are terminated prematurely. The nascent DNA remains stably associated with the template, forming a triple-stranded displacement loop (D-loop) structure. However, the function of the D-loop region of the mitochondrial genome remains poorly understo...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jemt, Elisabeth, Persson, Örjan, Shi, Yonghong, Mehmedovic, Majda, Uhler, Jay P., Dávila López, Marcela, Freyer, Christoph, Gustafsson, Claes M., Samuelsson, Tore, Falkenberg, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627069/
https://ncbi.nlm.nih.gov/pubmed/26253742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv804
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