The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities

The TWINKLE protein is a hexameric DNA helicase required for replication of mitochondrial DNA. TWINKLE displays striking sequence similarity to the bacteriophage T7 gene 4 protein (gp4), which is a bi-functional primase-helicase required at the phage DNA replication fork. The N-terminal domain of hu...

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Detalles Bibliográficos
Main Authors: Farge, Géraldine, Holmlund, Teresa, Khvorostova, Julia, Rofougaran, Reza, Hofer, Anders, Falkenberg, Maria
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241861/
https://ncbi.nlm.nih.gov/pubmed/18039713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1025
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