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Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase
TWINKLE is the helicase involved in replication and maintenance of mitochondrial DNA (mtDNA) in mammalian cells. Structurally, TWINKLE is closely related to the bacteriophage T7 gp4 protein and comprises a helicase and primase domain joined by a flexible linker region. Mutations in and around this l...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6423418/ https://ncbi.nlm.nih.gov/pubmed/30496414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy415 |
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