MiR-215 is induced post-transcriptionally via HIF-Drosha complex and mediates glioma-initiating cell adaptation to hypoxia by targeting KDM1B

The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here we report that hypoxia-induced miR-215 is vital for reprograming GICs to fit the hypoxic microenvironment via suppressing t...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Hu, Jing, Sun, Tao, Wang, Hui, Chen, Zhengxin, Wang, Shuai, Yuan, Lifeng, Liu, Tingyu, Li, Hai-Ri, Wang, Pingping, Feng, Yukuan, Wang, Qinhong, McLendon, Roger E., Friedman, Allan H., Keir, Stephen T., Bigner, Darell D., Rathmell, Jeff, Fu, Xiang-dong, Li, Qi-Jing, Wang, Huibo, Wang, Xiao-Fan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871949/
https://ncbi.nlm.nih.gov/pubmed/26766590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.12.005
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