A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

Usher syndrome type III (USH3) characterized by progressive deafness, variable balance disorder, and blindness is caused by destabilizing mutations in the gene encoding the clarin-1 protein (CLRN1). Here we report a novel strategy to mitigate hearing loss associated with a common USH3 mutation CLRN1...

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Опубликовано в: :Nat Chem Biol
Главные авторы: Alagramam, Kumar N., Gopal, Suhasini R., Geng, Ruishuang, Chen, Daniel H.-C., Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F., Lock, Christopher J., Esmieu, William R. K., Owens, Andrew P., Lindsay, Nicola A., Ouwehand, Krista, Albertus, Faywell, Fischer, David F., Bürli, Roland W., MacLeod, Angus M., Harte, William E., Palczewski, Krzysztof, Imanishi, Yoshikazu
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871731/
https://ncbi.nlm.nih.gov/pubmed/27110679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2069
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