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3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains an unvalidated antiviral target. A major challenge of specifically targeting HIV RNase H arises from the general lack of selectivity over RT polymerase (pol) and integrase (IN) strand transfer (...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Tang, Jing, Liu, Feng, Nagy, Eva, Miller, Lena, Kirby, Karen A., Wilson, Daniel J., Wu, Bulan, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871627/
https://ncbi.nlm.nih.gov/pubmed/26927866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01879
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