Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL

Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1. In human TAL1-driven T-ALL cell lines, Trib2 is proposed to function as an important survival factor, but there is limited information about...

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Vydáno v:PLoS One
Hlavní autoři: Stein, Sarah J., Mack, Ethan A., Rome, Kelly S., Pajcini, Kostandin V., Ohtani, Takuya, Xu, Lanwei, Li, Yunlei, Meijerink, Jules P. P., Faryabi, Robert B., Pear, Warren S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871414/
https://ncbi.nlm.nih.gov/pubmed/27191957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155408
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