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Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53. Further studies on its biological function and drug discovery init...

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Dettagli Bibliografici
Pubblicato in:Eur J Med Chem
Autori principali: Wapenaar, Hannah, van der Wouden, Petra E., Groves, Matthew R., Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871228/
https://ncbi.nlm.nih.gov/pubmed/26505788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.10.016
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