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Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity

Estrogen receptor-α (ERα) is a central transcription factor that regulates mammary gland physiology and a key driver in breast cancer. In the present study, we aimed to identify novel modulators of ERα-mediated transcriptional regulation via a custom-built siRNA library screen. This screen was direc...

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Bibliografische gegevens
Gepubliceerd in:Oncogene
Hoofdauteurs: Bolt, MJ, Stossi, F, Callison, AM, Mancini, MG, Dandekar, R, Mancini, MA
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871123/
https://ncbi.nlm.nih.gov/pubmed/24441042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.550
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