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High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes
Estrogen receptor-α (ER) is an important target both for therapeutic compounds and endocrine disrupting chemicals (EDCs); however, the mechanisms involved in chemical modulation of regulating ER transcriptional activity are inadequately understood. Here, we report the development of a high content a...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086628/ https://ncbi.nlm.nih.gov/pubmed/21256200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2011.01.009 |
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