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High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes

Estrogen receptor-α (ER) is an important target both for therapeutic compounds and endocrine disrupting chemicals (EDCs); however, the mechanisms involved in chemical modulation of regulating ER transcriptional activity are inadequately understood. Here, we report the development of a high content a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ashcroft, FJ, Newberg, JY, Jones, ED, Mikic, I, Mancini, MA
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086628/
https://ncbi.nlm.nih.gov/pubmed/21256200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2011.01.009
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