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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson’s disease(1). Recent studies of the Parkinson’s disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may...
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| Τόπος έκδοσης: | Nature |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841086/ https://ncbi.nlm.nih.gov/pubmed/24270810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12748 |
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