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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson’s disease(1). Recent studies of the Parkinson’s disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Hasson, Samuel A., Kane, Lesley A., Yamano, Koji, Huang, Chiu-Hui, Sliter, Danielle A., Buehler, Eugen, Wang, Chunxin, Heman-Ackah, Sabrina M., Hessa, Tara, Guha, Rajarshi, Martin, Scott E., Youle, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841086/
https://ncbi.nlm.nih.gov/pubmed/24270810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12748
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