High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson’s disease(1). Recent studies of the Parkinson’s disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may...

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Bibliografiset tiedot
Julkaisussa:Nature
Päätekijät: Hasson, Samuel A., Kane, Lesley A., Yamano, Koji, Huang, Chiu-Hui, Sliter, Danielle A., Buehler, Eugen, Wang, Chunxin, Heman-Ackah, Sabrina M., Hessa, Tara, Guha, Rajarshi, Martin, Scott E., Youle, Richard J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841086/
https://ncbi.nlm.nih.gov/pubmed/24270810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12748
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