High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson’s disease(1). Recent studies of the Parkinson’s disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may...

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Udgivet i:Nature
Main Authors: Hasson, Samuel A., Kane, Lesley A., Yamano, Koji, Huang, Chiu-Hui, Sliter, Danielle A., Buehler, Eugen, Wang, Chunxin, Heman-Ackah, Sabrina M., Hessa, Tara, Guha, Rajarshi, Martin, Scott E., Youle, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841086/
https://ncbi.nlm.nih.gov/pubmed/24270810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12748
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