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Chromatin looping as a target for altering erythroid gene expression

The β-hemoglobinopathies are the most common monogenic disorders in humans, with symptoms arising after birth when the fetal γ-globin genes are silenced and the adult β-globin gene is activated. There is a growing appreciation that genome organization and the folding of chromosomes are key determina...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Ann N Y Acad Sci
Main Authors: Krivega, Ivan, Dean, Ann
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870130/
https://ncbi.nlm.nih.gov/pubmed/26918894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13012
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