A LAIR-1 insertion generates broadly reactive antibodies against malaria variant antigens

Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies(1–4). Although broadly reactive antib...

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Udgivet i:Nature
Main Authors: Tan, Joshua, Pieper, Kathrin, Piccoli, Luca, Abdi, Abdirahman, Perez, Mathilde Foglierini, Geiger, Roger, Tully, Claire Maria, Jarrossay, David, Maina Ndungu, Francis, Wambua, Juliana, Bejon, Philip, Fregni, Chiara Silacci, Fernandez-Rodriguez, Blanca, Barbieri, Sonia, Bianchi, Siro, Marsh, Kevin, Thathy, Vandana, Corti, Davide, Sallusto, Federica, Bull, Peter, Lanzavecchia, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869849/
https://ncbi.nlm.nih.gov/pubmed/26700814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16450
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