An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed through an orthogonal array design, which demonstrates improved delivery efficiency of mRNA encoding luciferase in vitro b...

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Bibliografiske detaljer
Udgivet i:Nano Lett
Main Authors: Li, Bin, Luo, Xiao, Deng, Binbin, Wang, Junfeng, McComb, David W., Shi, Yimin, Gaensler, Karin M. L., Tan, Xu, Dunn, Amy L., Kerlin, Bryce A., Dong, Yizhou
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869688/
https://ncbi.nlm.nih.gov/pubmed/26529392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b03528
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