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An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed through an orthogonal array design, which demonstrates improved delivery efficiency of mRNA encoding luciferase in vitro b...
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| Publicado no: | Nano Lett |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869688/ https://ncbi.nlm.nih.gov/pubmed/26529392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b03528 |
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