Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase

BACKGROUND: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refractory schizophrenia. However, the clinical usage of clozapine is limited due to a high incidence of neutropenia or agranulocytosis. We previously reported that clozapine protected dopaminergic neuron...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Jiang, Lulu, Wu, Xuefei, Wang, Shuo, Chen, Shih-Heng, Zhou, Hui, Wilson, Belinda, Jin, Chun-Yang, Lu, Ru-Band, Xie, Keqin, Wang, Qingshan, Hong, Jau-Shyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869380/
https://ncbi.nlm.nih.gov/pubmed/27184631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0573-z
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