RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

Ras GTPases are activated by RasGEFs and inactivated by RasGAPs, which stimulate the hydrolysis of RasGTP to inactive RasGDP. GTPase-impairing somatic mutations in RAS genes, such as KRAS(G12D), are among the most common oncogenic events in metastatic cancer. A different type of cancer Ras signal, d...

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Udgivet i:Oncogene
Main Authors: Ksionda, O, Melton, AA, Bache, J, Tenhagen, M, Bakker, J, Harvey, R, Winter, SS, Rubio, I, Roose, JP
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868787/
https://ncbi.nlm.nih.gov/pubmed/26549032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.431
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