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Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities
Many p53 hotspot mutants not only lose the transcriptional activity, but also show dominant-negative (DN) and oncogenic gain-of-function (GOF) activities. Increasing evidence indicates that knockdown of mutant p53 (mutp53) in cancer cells reduces their aggressive properties, suggesting that survival...
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| Publié dans: | Oncotarget |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868694/ https://ncbi.nlm.nih.gov/pubmed/26700961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6634 |
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