Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities

Many p53 hotspot mutants not only lose the transcriptional activity, but also show dominant-negative (DN) and oncogenic gain-of-function (GOF) activities. Increasing evidence indicates that knockdown of mutant p53 (mutp53) in cancer cells reduces their aggressive properties, suggesting that survival...

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Vydáno v:Oncotarget
Hlavní autoři: Iyer, Swathi V., Parrales, Alejandro, Begani, Priya, Narkar, Akshay, Adhikari, Amit S., Martinez, Luis A., Iwakuma, Tomoo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868694/
https://ncbi.nlm.nih.gov/pubmed/26700961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6634
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