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Origin of aromatase inhibitory activity via proteochemometric modeling
Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor candidates with high selectivity, lower...
Uloženo v:
| Vydáno v: | PeerJ |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
PeerJ Inc.
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868594/ https://ncbi.nlm.nih.gov/pubmed/27190705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.1979 |
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