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A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms

A unified proteochemometric (PCM) model for the prediction of the ability of drug-like chemicals to inhibit five major drug metabolizing CYP isoforms (i.e. CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) was created and made publicly available under the Bioclipse Decision Support open source system at w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lapins, Maris, Worachartcheewan, Apilak, Spjuth, Ola, Georgiev, Valentin, Prachayasittikul, Virapong, Nantasenamat, Chanin, Wikberg, Jarl E. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684587/
https://ncbi.nlm.nih.gov/pubmed/23799117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066566
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