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Origin of aromatase inhibitory activity via proteochemometric modeling

Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor candidates with high selectivity, lower...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Simeon, Saw, Spjuth, Ola, Lapins, Maris, Nabu, Sunanta, Anuwongcharoen, Nuttapat, Prachayasittikul, Virapong, Wikberg, Jarl E.S., Nantasenamat, Chanin
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868594/
https://ncbi.nlm.nih.gov/pubmed/27190705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.1979
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