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Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex
Huntington disease (HD) is a neurological disorder caused by polyglutamine expansions in mutated Huntingtin (mHtt) proteins, rendering them prone to form inclusion bodies (IB). We report that in yeast, such IB formation is a factor-dependent process subjected to age-related decline. A genome-wide, h...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868537/ https://ncbi.nlm.nih.gov/pubmed/27033550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11792 |
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