Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

Huntington disease (HD) is a neurological disorder caused by polyglutamine expansions in mutated Huntingtin (mHtt) proteins, rendering them prone to form inclusion bodies (IB). We report that in yeast, such IB formation is a factor-dependent process subjected to age-related decline. A genome-wide, h...

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Udgivet i:eLife
Main Authors: Yang, Junsheng, Hao, Xinxin, Cao, Xiuling, Liu, Beidong, Nyström, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868537/
https://ncbi.nlm.nih.gov/pubmed/27033550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11792
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