Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires

Elucidating how antigen exposure and selection shape the human antibody repertoire is fundamental to our understanding of B-cell immunity. We sequenced the paired heavy- and light-chain variable regions (VH and VL, respectively) from large populations of single B cells combined with computational mo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: DeKosky, Brandon J., Lungu, Oana I., Park, Daechan, Johnson, Erik L., Charab, Wissam, Chrysostomou, Constantine, Kuroda, Daisuke, Ellington, Andrew D., Ippolito, Gregory C., Gray, Jeffrey J., Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868480/
https://ncbi.nlm.nih.gov/pubmed/27114511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525510113
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