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Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway
Nogalamycin, an aromatic polyketide displaying high cytotoxicity, has a unique structure, with one of the carbohydrate units covalently attached to the aglycone via an additional carbon–carbon bond. The underlying chemistry, which implies a particularly challenging reaction requiring activation of a...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868444/ https://ncbi.nlm.nih.gov/pubmed/27114534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525034113 |
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