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Divergent evolution of an atypical S-adenosyl-l-methionine–dependent monooxygenase involved in anthracycline biosynthesis

Bacterial secondary metabolic pathways are responsible for the biosynthesis of thousands of bioactive natural products. Many enzymes residing in these pathways have evolved to catalyze unusual chemical transformations, which is facilitated by an evolutionary pressure promoting chemical diversity. Su...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Grocholski, Thadée, Dinis, Pedro, Niiranen, Laila, Niemi, Jarmo, Metsä-Ketelä, Mikko
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538628/
https://ncbi.nlm.nih.gov/pubmed/26216966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501765112
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