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Divergent evolution of an atypical S-adenosyl-l-methionine–dependent monooxygenase involved in anthracycline biosynthesis

Bacterial secondary metabolic pathways are responsible for the biosynthesis of thousands of bioactive natural products. Many enzymes residing in these pathways have evolved to catalyze unusual chemical transformations, which is facilitated by an evolutionary pressure promoting chemical diversity. Su...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Grocholski, Thadée, Dinis, Pedro, Niiranen, Laila, Niemi, Jarmo, Metsä-Ketelä, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538628/
https://ncbi.nlm.nih.gov/pubmed/26216966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501765112
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