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Divergent evolution of an atypical S-adenosyl-l-methionine–dependent monooxygenase involved in anthracycline biosynthesis
Bacterial secondary metabolic pathways are responsible for the biosynthesis of thousands of bioactive natural products. Many enzymes residing in these pathways have evolved to catalyze unusual chemical transformations, which is facilitated by an evolutionary pressure promoting chemical diversity. Su...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538628/ https://ncbi.nlm.nih.gov/pubmed/26216966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501765112 |
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