Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice

Low oxygen tension (hypoxia) regulates chondrocyte differentiation and metabolism. Hypoxia-inducible factor 1α (HIF1α) is a crucial hypoxic factor for chondrocyte growth and survival during development. The major metalloproteinase matrix metalloproteinase 13 (MMP13) is also associated with chondrocy...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Bouaziz, Wafa, Sigaux, Johanna, Modrowski, Dominique, Devignes, Claire-Sophie, Funck-Brentano, Thomas, Richette, Pascal, Ea, Hang-Korng, Provot, Sylvain, Cohen-Solal, Martine, Haÿ, Eric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868441/
https://ncbi.nlm.nih.gov/pubmed/27122313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514854113
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