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Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination

BACKGROUND: We previously reported the case of a 64-year-old man with mediastinitis caused by Staphylococcus aureus in which the infecting bacterium acquired linezolid resistance after only 14 days treatment with linezolid. We therefore investigated relevant clinical isolates for possible mechanisms...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Iguchi, Shigekazu, Mizutani, Tomonori, Hiramatsu, Keiichi, Kikuchi, Ken
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868352/
https://ncbi.nlm.nih.gov/pubmed/27182700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155512
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