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Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination

BACKGROUND: We previously reported the case of a 64-year-old man with mediastinitis caused by Staphylococcus aureus in which the infecting bacterium acquired linezolid resistance after only 14 days treatment with linezolid. We therefore investigated relevant clinical isolates for possible mechanisms...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Iguchi, Shigekazu, Mizutani, Tomonori, Hiramatsu, Keiichi, Kikuchi, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868352/
https://ncbi.nlm.nih.gov/pubmed/27182700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155512
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