Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia

High levels of microRNA-155 (miR-155) are associated with poor outcome in acute myeloid leukemia (AML). In AML, miR-155 is regulated by NF-κB, the activity of which is, in part, controlled by the NEDD8-dependent ubiquitin ligases. We demonstrate that MLN4924, an inhibitor of NEDD8-activating enzyme...

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Pubblicato in:Leukemia
Autori principali: Khalife, J, Radomska, HS, Santhanam, R, Huang, X, Neviani, P, Saultz, J, Wang, H, Wu, Y-Z, Alachkar, H, Anghelina, M, Dorrance, A, Curfman, J, Bloomfield, CD, Medeiros, BC, Perrotti, D, Lee, LJ, Lee, RJ, Caligiuri, MA, Pichiorri, F, Croce, CM, Garzon, R, Guzman, ML, Mendler, JH, Marcucci, G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868182/
https://ncbi.nlm.nih.gov/pubmed/25971362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.106
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