Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

[Image: see text] A novel series of covalent inhibitors of EGFR (epidermal growth factor receptor) kinase was discovered through a combination of subset screening and structure-based design. These compounds preferentially inhibit mutant forms of EGFR (activating mutant and T790M mutant) over wild-ty...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Hennessy, Edward J., Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P., Sha, Li, Wu, Xiaoyun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2016
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867489/
https://ncbi.nlm.nih.gov/pubmed/27190603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00058
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