Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

[Image: see text] A novel series of covalent inhibitors of EGFR (epidermal growth factor receptor) kinase was discovered through a combination of subset screening and structure-based design. These compounds preferentially inhibit mutant forms of EGFR (activating mutant and T790M mutant) over wild-ty...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:ACS Med Chem Lett
Κύριοι συγγραφείς: Hennessy, Edward J., Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P., Sha, Li, Wu, Xiaoyun
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2016
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867489/
https://ncbi.nlm.nih.gov/pubmed/27190603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00058
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