The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

nork Butterworth, Sam, Cross, Darren A. E., Finlay, M. Raymond V., Ward, Richard A., Waring, Michael J.
Argitaratua izan da Medchemcomm (2017)

Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib

nork Liu, Shengwu, Li, Shuai, Hai, Josephine, Wang, Xiaoen, Chen, Ting, Quinn, Max M., Gao, Peng, Zhang, Yanxi, Ji, Hongbin, Cross, Darren A.E., Wong, Kwok-Kin
Argitaratua izan da Clin Cancer Res (2018)

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

nork Hennessy, Edward J., Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P., Sha, Li, Wu, Xiaoyun
Argitaratua izan da ACS Med Chem Lett (2016)

Optimizing the sequence of anti-EGFR targeted therapy in EGFR-mutant lung cancer

nork Meador, Catherine B., Jin, Hailing, de Stanchina, Elisa, Nebhan, Caroline A., Pirazzoli, Valentina, Wang, Lu, Lu, Pengcheng, Vuong, Huy, Hutchinson, Katherine E., Jia, Peilin, Chen, Xi, Eisenberg, Rosana, Ladanyi, Marc, Politi, Katerina, Zhao, Zhongming, Lovly, Christine M., Cross, Darren A. E., Pao, William
Argitaratua izan da Mol Cancer Ther (2014)

Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models

nork Eberlein, Catherine A., Stetson, Daniel, Markovets, Aleksandra A., Al-Kadhimi, Katherine J., Lai, Zhongwu, Fisher, Paul R., Meador, Catherine B., Spitzler, Paula, Ichihara, Eiki, Ross, Sarah J., Ahdesmaki, Miika J., Ahmed, Ambar, Ratcliffe, Laura E., Christey O’Brien, Elizabeth L., Barnes, Claire H., Brown, Henry, Smith, Paul D., Dry, Jonathan R., Beran, Garry, Thress, Kenneth S., Dougherty, Brian, Pao, William, Cross, Darren A. E.
Argitaratua izan da Cancer Res (2015)

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

nork Cross, Darren A. E., Ashton, Susan E., Ghiorghiu, Serban, Eberlein, Cath, Nebhan, Caroline A., Spitzler, Paula J., Orme, Jonathon P., Finlay, M. Raymond V., Ward, Richard A., Mellor, Martine J., Hughes, Gareth, Rahi, Amar, Jacobs, Vivien N., Brewer, Monica Red, Ichihara, Eiki, Sun, Jing, Jin, Hailing, Ballard, Peter, Al-Kadhimi, Katherine, Rowlinson, Rachel, Klinowska, Teresa, Richmond, Graham H. P., Cantarini, Mireille, Kim, Dong-Wan, Ranson, Malcolm R., Pao, William
Argitaratua izan da Cancer Discov (2014)