Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

[Image: see text] The identification of a new series of P. falciparum growth inhibitors is described. Starting from a series of known human class I HDAC inhibitors a SAR exploration based on growth inhibitory activity in parasite and human cells-based assays led to the identification of compounds wi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Ontoria, Jesus M., Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V., Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867480/
https://ncbi.nlm.nih.gov/pubmed/27190592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00468
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