Regulation of myofibroblast differentiation by cardiac glycosides

Myofibroblast differentiation is a key process in pathogenesis of fibrotic diseases. Cardiac glycosides (ouabain, digoxin) inhibit Na(+)-K(+)-ATPase, resulting in increased intracellular [Na(+)]-to-[K(+)] ratio in cells. Microarray analysis suggested that increased intracellular [Na(+)]/[K(+)] ratio...

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Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: La, Jennifer, Reed, Eleanor B., Koltsova, Svetlana, Akimova, Olga, Hamanaka, Robert B., Mutlu, Gökhan M., Orlov, Sergei N., Dulin, Nickolai O.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867347/
https://ncbi.nlm.nih.gov/pubmed/26851261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00322.2015
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